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Case 3 A 5-year-old child who weighs 55 lb is suffering from an infection. He was ordered Pathocil (Dicloxacillin Sodium) 125 mg P.O. q. 6 h . The recommended dosage of Pathocil for children weighing less than 40 kg is \( 12.5-25 \mathrm{mg} / \mathrm{kg} / \) day P.O in equally divided doses q .6 h for moderate to severe infections. Calculate the following - Recommended minimum daily dosage for this child:. \( \qquad \) .mg/day - Recommended minimum single dosage for this child: \( \qquad \) .mg/dose - Recommended maximum daily dosage for this child: \( \qquad \) mg/day - Recommended maximum single dosage for this child: - Decide if the dose is safe or not ? .mg/dose

Ask by Sherman Grant. in Egypt
Feb 25,2025

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Answer

- **Recommended minimum daily dosage:** ≈312.5 mg/day - **Recommended minimum single dosage:** ≈78 mg/dose - **Recommended maximum daily dosage:** ≈625 mg/day - **Recommended maximum single dosage:** ≈156 mg/dose - **Safety:** The prescribed dose of 125 mg/dose (500 mg/day) is within the recommended range and is safe.

Solution

Step 1. Convert weight if needed: • 55 lb ÷ 2.2 = 25 kg (approximately) Step 2. Calculate the daily dosage range using 12.5–25 mg/kg/day: • Minimum daily dosage = 12.5 mg/kg × 25 kg = 312.5 mg/day • Maximum daily dosage = 25 mg/kg × 25 kg = 625 mg/day Step 3. Since the doses are to be given every 6 hours (i.e. 4 equally divided doses per day), determine the per-dose amounts: • Minimum dose (per dose) = 312.5 mg ÷ 4 = 78.125 mg/dose (approximately 78 mg/dose) • Maximum dose (per dose) = 625 mg ÷ 4 = 156.25 mg/dose (approximately 156 mg/dose) Step 4. Compare with the ordered dose: • Ordered dose = 125 mg PO every 6 hours, which gives a total daily dose of 125 mg × 4 = 500 mg/day. • 125 mg per dose lies between the minimum recommended of approximately 78 mg/dose and the maximum of approximately 156 mg/dose. Conclusion: • Recommended minimum daily dosage: ≈312.5 mg/day • Recommended minimum single dosage: ≈78 mg/dose • Recommended maximum daily dosage: ≈625 mg/day • Recommended maximum single dosage: ≈156 mg/dose • The prescribed dose of 125 mg/dose (500 mg/day) is within the recommended range and is considered safe.

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To calculate the dosages for the child, we'll use the weight of the child (55 lb), convert it to kg, and then calculate the recommended dosages based on the provided information. 1. **Convert weight:** \( 55 \text{ lb} \div 2.2 \text{ lb/kg} \approx 25 \text{ kg} \) 2. **Recommended minimum daily dosage:** Minimum dosage: \( 12.5 \text{ mg/kg/day} \) \( 12.5 \text{ mg/kg} \times 25 \text{ kg} = 312.5 \text{ mg/day} \) 3. **Recommended minimum single dosage:** This is the minimum daily dosage divided by the number of doses per day (4 doses). \( 312.5 \text{ mg/day} \div 4 \text{ doses/day} = 78.125 \text{ mg/dose} \) 4. **Recommended maximum daily dosage:** Maximum dosage: \( 25 \text{ mg/kg/day} \) \( 25 \text{ mg/kg} \times 25 \text{ kg} = 625 \text{ mg/day} \) 5. **Recommended maximum single dosage:** This is the maximum daily dosage divided by the number of doses per day (4 doses). \( 625 \text{ mg/day} \div 4 \text{ doses/day} = 156.25 \text{ mg/dose} \) 6. **Decide if the dose is safe or not:** The ordered dose is 125 mg/dose. - Minimum: 78.125 mg/dose - Maximum: 156.25 mg/dose Since 125 mg/dose is within the safe range (between 78.125 mg and 156.25 mg), the dose is **safe**. - Recommended minimum daily dosage for this child: **312.5 mg/day** - Recommended minimum single dosage for this child: **78.125 mg/dose** - Recommended maximum daily dosage for this child: **625 mg/day** - Recommended maximum single dosage for this child: **156.25 mg/dose** - The dose is safe: **Yes, 125 mg/dose** is safe.

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