STION 3 the information below. ene, VKORC1, codes for a blood-clotting factor in humans. This gene is mat amino acids. utation occurred that affected amino acid 128 and 139, the sequence CTG med to CAG and the TAT became TCT. e treatment of thrombosis. Thrombosis results in the formation of a blood c ritery. Warfarin causes the thinning of blood to break down the blood clot. Give ONE piece of evidence from the information that shows that the mutation for this gene occurred in the DNA molecule. How many nitrogenous bases code for the VKORC1 gene? The table below shows the amino acids and their corresponding

To address the questions based on the provided information about the VKORC1 gene and its mutations, let's break down the problem step by step. ### Step 1: Evidence of Mutation in the DNA Molecule The information states that a mutation occurred affecting amino acids 128 and 139, where the sequence CTG changed to CAG and TAT changed to TCT. This change in the nucleotide sequence is direct evidence of a mutation in the DNA molecule. Specifically, the alteration of the DNA sequence (from CTG to CAG and TAT to TCT) indicates that the genetic code has been modified, which is a hallmark of a mutation. ### Step 2: Number of Nitrogenous Bases Coding for the VKORC1 Gene To determine how many nitrogenous bases code for the VKORC1 gene, we need to know the length of the gene in terms of amino acids and the fact that each amino acid is typically coded by a triplet of nitrogenous bases (codon). 1. **Identify the number of amino acids coded by VKORC1**: The specific number of amino acids in the VKORC1 gene is not provided in the information given. However, if we assume that the VKORC1 gene codes for a certain number of amino acids (let's denote this number as \( n \)), then the total number of nitrogenous bases would be calculated as follows: \[ \text{Total nitrogenous bases} = n \times 3 \] 2. **Example Calculation**: If VKORC1 codes for, say, 150 amino acids, then the total number of nitrogenous bases would be: \[ \text{Total nitrogenous bases} = 150 \times 3 = 450 \] Without the specific number of amino acids coded by VKORC1, we cannot provide an exact number of nitrogenous bases. If you have that information, please provide it, and I can calculate the exact number of nitrogenous bases for you. ### Conclusion 1. **Evidence of Mutation**: The change in the DNA sequence from CTG to CAG and TAT to TCT is evidence of a mutation. 2. **Nitrogenous Bases**: The total number of nitrogenous bases coding for the VKORC1 gene can be calculated as \( n \times 3 \), where \( n \) is the number of amino acids coded by the gene. If you have the specific number of amino acids, please share it for a precise calculation.