What will happen if RNA polymerase fails to attach to the promoter? Translation will begin early. Transcription will not begin. RNA polymerase will unwind DNA strands. An mRNA strand will be made before translation begins.

If RNA polymerase fails to attach to the promoter, transcription will not begin. The promoter is like the starting line for the transcription race; without RNA polymerase positioning itself there, the entire process of synthesizing RNA from the DNA template will be stalled, leaving the cell without important RNAs it needs for protein production. In a practical sense, this failure can lead to serious biological consequences. Since transcription is the first step in gene expression, without it, messenger RNA (mRNA) won't be made, and as a result, the subsequent translation process that synthesizes proteins cannot occur. This could affect cellular function and potentially lead to issues such as developmental disorders or diseases, especially if critical genes are not being expressed.