The nurse is caring for a newly admitted client with Cushing syndrome. Which statement explains why the nurse would monitor this client for clinical indicators of diabetes mellitus? Cortical hormones stimulate rapid weight loss. Tissue catabolism results in a negative nitrogen balance. Glucocorticoids accelerate the process of gluconeogenesis. Excessive adrenocorticotropic hormone (ACTH) secretion damages pancreatic tissue.

Glucocorticoids, which are elevated in Cushing syndrome, lead to increased glucose production in the liver through gluconeogenesis, raising blood sugar levels. This sustained hyperglycemia can result in the development of diabetes mellitus over time, making it essential for nurses to stay vigilant for indicators of glucose intolerance in these patients. Additionally, Cushing syndrome often involves an imbalance in various hormones that can lead to insulin resistance. The excessive cortisol can interfere with the normal action of insulin, making it hard for cells to absorb glucose from the bloodstream, thereby heightening the risk of diabetes. Regular monitoring can catch these changes early and improve patient management.