$$ t $$ LEVOTHYROXINE NDC 55390-880-10 Usual Dosage: See insert for complete information. Vial contalns 200 mcg levothyroxine sodium, 10 mg mannitol, 0.7 mg tribasic sodium phosphate, and sodium hydroxide for pH adjustment. Use immediately after reconstitution with 5 mL . of $$ 0.9 \% $$ sodium chloride injection, USP only. Reconstituted concentration is $$ 40 \mathrm{mcg} / \mathrm{mL} $$. Preservative free. Discard any unused portion. Store at controlled room temperature, $$ 15^{\circ} $$ to $$ 30^{\circ} \mathrm{C}\left(59^{\circ} ight. $$ to $$ \left.86^{\circ} \mathrm{F} ight) $$. Manutactured for: Bedford Laboratories $$ { }^{ ext {™ }} $$ Bedford, OH 44146 LTR-V04 What volume of diluent (in milliliters) must you add to prepare the solution for use? $$ \qquad $$ mL eBook

Question

$$ t $$ LEVOTHYROXINE NDC 55390-880-10 Usual Dosage: See insert for complete information. Vial contalns 200 mcg levothyroxine sodium, 10 mg mannitol, 0.7 mg tribasic sodium phosphate, and sodium hydroxide for pH adjustment. Use immediately after reconstitution with 5 mL . of $$ 0.9 \% $$ sodium chloride injection, USP only. Reconstituted concentration is $$ 40 \mathrm{mcg} / \mathrm{mL} $$. Preservative free. Discard any unused portion. Store at controlled room temperature, $$ 15^{\circ} $$ to $$ 30^{\circ} \mathrm{C}\left(59^{\circ}ight. $$ to $$ \left.86^{\circ} \mathrm{F}ight) $$. Manutactured for: Bedford Laboratories $$ { }^{	ext {™ }} $$ Bedford, OH 44146 LTR-V04 What volume of diluent (in milliliters) must you add to prepare the solution for use? $$ \qquad $$ mL eBook

UpStudy AI · Accepted Answer

To prepare the solution for use, we need to determine the volume of diluent (sodium chloride injection) required to achieve the desired concentration of $$ 40 \, \text{mcg/mL} $$ after reconstitution.

### Known Conditions:
1. The vial contains $$ 200 \, \text{mcg} $$ of levothyroxine sodium.
2. The desired concentration after reconstitution is $$ 40 \, \text{mcg/mL} $$.

### Step-by-Step Solution:

1. **Determine the total volume needed to achieve the desired concentration:**
   We can use the formula for concentration:
   $$
   \text{Concentration} = \frac{\text{Amount of solute}}{\text{Volume of solution}}
   $$
   Rearranging this gives us:
   $$
   \text{Volume of solution} = \frac{\text{Amount of solute}}{\text{Concentration}}
   $$

2. **Substituting the known values:**
   - Amount of solute (levothyroxine) = $$ 200 \, \text{mcg} $$
   - Desired concentration = $$ 40 \, \text{mcg/mL} $$

Plugging in these values:
   $$
   \text{Volume of solution} = \frac{200 \, \text{mcg}}{40 \, \text{mcg/mL}} = 5 \, \text{mL}
   $$

3. **Determine the volume of diluent to add:**
   The instructions state to use $$ 5 \, \text{mL} $$ of diluent for reconstitution. Since we need a total volume of $$ 5 \, \text{mL} $$ to achieve the desired concentration, we will add $$ 5 \, \text{mL} $$ of the diluent.

### Final Answer:
The volume of diluent that must be added to prepare the solution for use is $$ 5 \, \text{mL} $$.
You need to add 5 mL of diluent to prepare the solution for use.

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