Multiple Choice Question Why does the FDA limit the amount of folic acid in supplements to 400 micrograms? Large amounts of folate can mask an iron deficiency. Large amounts of the natural form of folate can be toxic. Large amounts of folate can lead to birth defects.

Taking large amounts of folate, especially in synthetic forms like folic acid, can interfere with the body's ability to absorb and utilize other important nutrients, such as iron. This can result in an iron deficiency that might go unnoticed, which is particularly concerning for populations at risk, like pregnant women. In addition to nutrient interactions, excessive folate can contribute to health issues, especially in those with undiagnosed vitamin B12 deficiency. This can lead to neurological problems and other complications. Therefore, the FDA has set this limit to help prevent such adverse effects while still allowing for adequate supplementation.